LOINC Panel Details 71775-1 Mycobacterium tuberculosis stimulated gamma interferon panel

71776-9 Gamma interferon background [Units/volume] in Blood by Immunoassay

Term Description

This represents the baseline value for interferon-gamma release assays (IGRA). Elevated levels of IFN-gamma in the background ("Nil") sample may occur with the presence of heterophile antibodies, or to intrinsic IFN-gamma secretion.
Source: Regenstrief LOINC

Observation Required in Panel

Optional

Fully-Specified Name

Component: Gamma interferon background
Property: ACnc
Time: Pt
System: Bld
Scale: Qn
Method: IA

Additional Names

Short Name: Gamma interferon background Bld IA-aCnc
Display Name: Gamma interferon background IA Qn (Bld)
Consumer Name Alpha Get Info: Gamma interferon background, Blood

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.40
Last Updated: Version 2.73
Change Reason: Release 2.69: DefinitionDescription: Removed reference to QuantiFERON-TB assay from the description because this term is not specific for that assay.; Previous Releases: The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Observation
Common Test Rank Get Info: 596

Member of these Panels

LOINC	Long Common Name
71775-1	Mycobacterium tuberculosis stimulated gamma interferon panel - Blood
95974-2	SARS-CoV-2 stimulated gamma interferon panel - Blood

Language Variants Get Info

Tag	Language	Translation
de-AT	German (Austria)	Synonyms: TBN-induz. IFN-G LW
es-ES	Spanish (Spain)	Interferón gamma basal:Concentración arbitraria:Punto temporal:Sangre:Qn:IA Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Fondo de interferón gamma:Concentración arbitraria:Punto temporal:Sangre:Cuantitativo:Inmunoensayo
fr-FR	French (France)	Interféron gamma bruit de fond:Arbitraire/Volume:Ponctuel:Sang:Numérique:Immunoanalyse
it-IT	Italian (Italy)	Interferone gamma, background:ACnc:Pt:Sangue:Qn:IA Synonyms: Concentrazione Arbitraria Immunoassay Microbiologia Punto nel tempo (episodio) Sangue
nl-NL	Dutch (Netherlands)	gamma-interferon achtergrond:eenheid/volume:moment:bloed:kwantitatief:immunoassay Synonyms: IA
pt-BR	Portuguese (Brazil)	Gama interferon background::Pt:SgTotal:Qn:Imunoensaio
ru-RU	Russian (Russian Federation)	Гамма интерферон фон:ПроизвКонц:ТчкВрм:Кр:Колич:IA Synonyms: Количественный Кровь Произвольная концентрация Точка во времени;Момент
tr-TR	Turkish (Turkey)	Gamma interferon ardalan:SçKons:Zmlı:Kan:Kant:İA Synonyms: İmmünölçüm, immünoassay
zh-CN	Chinese (China)	Gamma 干扰素本底:任意型浓度:时间点:全血:定量型:免疫测定法 Synonyms: Gamma 干扰素（γ干扰素、IFN-γ）本底（背景） IFN 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验可用数量表示的;定量性;数值型;数量型;连续数值型标尺微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）时刻;随机;随意;瞬间血;血液

Example Units

Unit	Source
[IU]/mL	Example UCUM Units

71772-8 Mitogen stimulated gamma interferon [Units/volume] in Blood

Term Description

In the Quantiferon Gold test, the Mitogen-stimulated plasma sample serves as an IFN-gamma positive control for each specimen tested. A low response to Mitogen (<0.5 IU/mL) indicates an Indeterminate result when a blood sample also has a negative response to the TB antigens. This pattern may occur with insufficient lymphocytes, reduced lymphocyte activity due to prolonged specimen transport or improper specimen handling, including filling/mixing of blood tubes, or inability of the patient's lymphocytes to generate IFN-gamma.
Source: Regenstrief LOINC

Observation Required in Panel

Optional

Fully-Specified Name

Component: Mitogen stimulated gamma interferon
Property: ACnc
Time: Pt
System: Bld
Scale: Qn
Method

Additional Names

Short Name: Mitogen IGNF Bld-aCnc
Display Name: Mitogen stimulated gamma interferon Qn (Bld)
Consumer Name Alpha Get Info: Mitogen stimulated gamma interferon, Blood

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.40
Last Updated: Version 2.73
Order vs. Observation: Observation
Common Test Rank Get Info: 1663

Member of these Panels

LOINC	Long Common Name
53703-5	Mycobacterium bovis tuberculin stimulated gamma interferon panel - Blood
71775-1	Mycobacterium tuberculosis stimulated gamma interferon panel - Blood
95974-2	SARS-CoV-2 stimulated gamma interferon panel - Blood

Language Variants Get Info

Tag	Language	Translation
es-ES	Spanish (Spain)	Estimulacion mitogenica con gamma interferon:Concentración arbitraria:Punto temporal:Sangre:Qn: Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Interferón gamma estimulado por mitógenos:Concentración arbitraria:Punto temporal:Sangre:Cuantitativo:
fr-FR	French (France)	Interféron gamma stimulé par mitogène:Arbitraire/Volume:Ponctuel:Sang:Numérique:
it-IT	Italian (Italy)	Interferone gamma stimolato da mitogeno:ACnc:Pt:Sangue:Qn: Synonyms: Concentrazione Arbitraria Microbiologia Punto nel tempo (episodio) Sangue
nl-NL	Dutch (Netherlands)	mitogeen gestimuleerd gamma-interferon:eenheid/volume:moment:bloed:kwantitatief:
pt-BR	Portuguese (Brazil)	Mitógeno de gama interferon estimulada::Pt:SgTotal:Qn:
ru-RU	Russian (Russian Federation)	Митоген стимулированный гамма интерферон:ПроизвКонц:ТчкВрм:Кр:Колич: Synonyms: Количественный Кровь Произвольная концентрация Точка во времени;Момент
tr-TR	Turkish (Turkey)	Mitojen uyarılı gamma interferon:SçKons:Zmlı:Kan:Kant:
zh-CN	Chinese (China)	丝裂原刺激型 gamma 干扰素:任意型浓度:时间点:全血:定量型: Synonyms: IFN 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度可用数量表示的;定量性;数值型;数量型;连续数值型标尺干扰素.gamma 丝裂原刺激;丝裂原刺激型γ干扰素;丝裂原刺激型 IFN-γ 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）时刻;随机;随意;瞬间血;血液

Example Units

Unit	Source
[IU]/mL	Example UCUM Units

71774-4 Mitogen stimulated gamma interferon [Units/volume] corrected for background in Blood

Term Description

This is used as a positive control in interferon-gamma release assays.
Source: Regenstrief LOINC

Observation Required in Panel

Optional

Fully-Specified Name

Component: Mitogen stimulated gamma interferon^^corrected for background
Property: ACnc
Time: Pt
System: Bld
Scale: Qn
Method

Additional Names

Short Name: Mitogen IGNF bckgrd cor Bld-aCnc
Display Name: Mitogen stimulated gamma interferon corrected for background Qn (Bld)
Consumer Name Alpha Get Info: Mitogen stimulated gamma interferon Corrected for Background, Blood

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.40
Last Updated: Version 2.73
Change Reason: Release 2.69: DefinitionDescription: Broaden use of this term for other IGRA other than Quantiferon TB assay.;
Order vs. Observation: Observation
Common Test Rank Get Info: 575

Member of these Panels

LOINC	Long Common Name
71775-1	Mycobacterium tuberculosis stimulated gamma interferon panel - Blood
95974-2	SARS-CoV-2 stimulated gamma interferon panel - Blood

Language Variants Get Info

Tag	Language	Translation
de-AT	German (Austria)	Synonyms: TBN-induz. IFN-G LWK
es-ES	Spanish (Spain)	Estimulacion mitogenica con gamma interferon^^Corregido por ruido de fondo:Concentración arbitraria:Punto temporal:Sangre:Qn: Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Interferón gamma estimulado por mitógenos ^^ corregido para el fondo:Concentración arbitraria:Punto temporal:Sangre:Cuantitativo:
fr-FR	French (France)	Interféron gamma stimulé par mitogène corrigée par le bruit de fond:Arbitraire/Volume:Ponctuel:Sang:Numérique:
it-IT	Italian (Italy)	Interferone gamma stimolato da mitogeno^^corretto per background:ACnc:Pt:Sangue:Qn: Synonyms: Concentrazione Arbitraria Microbiologia Punto nel tempo (episodio) Sangue
nl-NL	Dutch (Netherlands)	mitogeen gestimuleerd gamma-interferon^^gecorrigeerd voor achtergrond:eenheid/volume:moment:bloed:kwantitatief:
pt-BR	Portuguese (Brazil)	Mitógeno de gama interferon estimulada^^corrigido para background::Pt:SgTotal:Qn:
ru-RU	Russian (Russian Federation)	Митоген стимулированный гамма интерферон^^поправленный на фон:ПроизвКонц:ТчкВрм:Кр:Колич: Synonyms: Количественный Кровь поправленный на шум;поправленный на окружение Произвольная концентрация Точка во времени;Момент
tr-TR	Turkish (Turkey)	Mitojen uyarılı gamma interferon^^düzeltilmiş artalanına göre:SçKons:Zmlı:Kan:Kant:
zh-CN	Chinese (China)	丝裂原刺激型 gamma 干扰素^^经过针对本底而校正的:任意型浓度:时间点:全血:定量型: Synonyms: IFN 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度可用数量表示的;定量性;数值型;数量型;连续数值型标尺干扰素.gamma 丝裂原刺激;丝裂原刺激型γ干扰素;丝裂原刺激型 IFN-γ 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）时刻;随机;随意;瞬间经过针对背景而校正的血;血液

Example Units

Unit	Source
[IU]/mL	Example UCUM Units

46217-6 Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] in Blood

Term Description

The quantitative levels (not corrected for background) for an IFN-gamma response by CD4+ T-helper lymphocytes stimulated by the presence of TB antigens, such as ESAT-6 and CFP-10.
Source: Regenstrief LOINC

Part Descriptions

LP14443-3 CD4
Found on helper T-cells; weakly expressed on monocytes.
Associated with some mature T-cell neoplasms, including most cases of T-cell CLL/prolymphocytic leukemia, peripheral
T-cell lymphoma, adult T-cell leukemia/lymphoma and Sézary syndrome/mycosis fungoides Source: Regenstrief LOINC

Observation Required in Panel

Optional

Fully-Specified Name

Component: Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells
Property: ACnc
Time: Pt
System: Bld
Scale: Qn
Method

Additional Names

Short Name: M TB IFN-g CD4+ T-cells Bld-aCnc
Display Name: M. tuberculosis stim IFN-g by CD4+ T-cells Qn (Bld)
Consumer Name Alpha Get Info: Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells, Blood

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.19
Last Updated: Version 2.73
Change Reason: In order to distinguish this test from a newer IFN-gamma response assay, the Component was updated to include "by helper CD4 cells" to clarify that this assay detects IFN-gamma response by CD4+ T-helper cells only. A newer assay uses this test as well as a separate assay to detect IFN-gamma response by both helper CD4 and cytotoxic CD8 cells. Changed Component from Mycobacterium tuberculosis stimulated gamma interferon release by helper CD4 cells to Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells to be consistant with LOINC cell marker naming conventions.
Order vs. Observation: Both
Common Test Rank Get Info: 1509

Member of these Panels

LOINC	Long Common Name
71775-1	Mycobacterium tuberculosis stimulated gamma interferon panel - Blood

Language Variants Get Info

Tag	Language	Translation
de-DE	German (Germany)	Mycobacterium-tuberculosis-stimulierte Gamma-Interferon-Freisetzung durch CD4+ T-Zellen:Arbiträre Konzentration:Zeitpunkt:Blut:Quantitativ:
es-ES	Spanish (Spain)	IFNγ liberado por células T CD4 estimuladas por Mycobacterium tuberculosis:Concentración arbitraria:Punto temporal:Sangre:Qn: Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Mycobacterium tuberculosis estimuló la liberación de interferón gamma por células T CD4 +:Concentración arbitraria:Punto temporal:Sangre:Cuantitativo:
fr-FR	French (France)	Interféron gamma libéré par cellules CD4+ stimulées par mycobacterium tuberculosis:Arbitraire/Volume:Ponctuel:Sang:Numérique:
fr-CA	French (Canada)	Mycobacterium tuberculosis, stimulation par le gamma Interféron par CD4+ T-cellules:Concentration arbitraire:Temps ponctuel:Sang:Quantitatif:
it-IT	Italian (Italy)	Mycobacterium tuberculosis, gamma interferone stimolato rilascio da CD4+ cellule T:ACnc:Pt:Sangue:Qn: Synonyms: Concentrazione Arbitraria Gamma interferone stimolato da Mycobacterium tuber Micobatterio della tubercolosi Microbiologia Punto nel tempo (episodio) Sangue
nl-NL	Dutch (Netherlands)	Mycobacterium tuberculosis-gestimuleerde gamma-interferon-release door CD4+-T-cellen:eenheid/volume:moment:bloed:kwantitatief:
pt-BR	Portuguese (Brazil)	Tuberculina, Mycobacterium tuberculosis estimulada interferon gamma:ACnc:Pt:SgTotal:Qn: Synonyms: ; TB; M TB tuberc IGNF; QFT; Quantiferon; Mycobacterium tuberculosum; M tuberculosis; Mtb; IFN; Arbitrary concentration; Point in time; Random; Blood; WB; Whole blood; Quantitative; QNT; Quant; Quan; Tuberculosis antigen; PPD; Purified protein derivative; IGRA; Acid Fast Bacilli; Mycobact; Myco; AFB; Acid fast bacillus; Microbiology
zh-CN	Chinese (China)	CD4+ T-细胞所释放的结核分枝杆菌刺激型 gamma 干扰素:任意型浓度:时间点:全血:定量型: Synonyms: AFB CD4+ T-细胞（CD4+ T细胞、CD4+ T淋巴细胞）所释放的结核分枝杆菌刺激型 gamma 干扰素（γ干扰素、IFN-γ） IFN L3T4 Leu3 Leu-3 T4 T-4 W3/25 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度分支杆菌分支杆菌属分枝杆菌属劳瘵发现于辅助 T-细胞；微弱表达于单核细胞。与相关。一些成熟 T-细胞肿瘤，包括大多数情况下的 T-细胞慢性淋巴细胞白血病/前淋巴细胞白血病、外周 T-细胞淋巴瘤、成人 T-细胞白血病/淋巴瘤以及 Sézary 综合征（T 细胞红皮病）/蕈样肉芽肿（mycosis fungoides）。可用数量表示的;定量性;数值型;数量型;连续数值型标尺微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）抗酸抗酸杆菌抗酸杆菌（Acid fast bacillus，AFB）抗酸菌时刻;随机;随意;瞬间痨痨病细胞含量;细胞性;细胞性质;细胞构成;细胞类结核结核;肺结核;痨;痨病;TB 结核分支杆菌;结核杆菌;结核菌结核分枝杆菌刺激型 gamma 干扰素（γ干扰素、IFN-γ）结核病肺结核血;血液诱导 T 细胞诱导性 T 细胞辅助 T 细胞辅助诱导 T 细胞辅助诱导物 T 细胞

Example Units

Unit	Source
[IU]/mL	Example UCUM Units
units/mL	REGENSTRIEF

64084-7 Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

Term Description

The quantitative levels (corrected for background) for an IFN-gamma response by CD4+ T-helper lymphocytes stimulated by the presence of TB antigens, such as ESAT-6 and CFP-10. The amount of IFN-gamma may be measured by enzyme-linked immunosorbent assay and reported in IU/mL. Results are adjusted for background, heterophile antibody effects, or nonspecific IFN-gamma in blood samples.
Source: Regenstrief LOINC

Part Descriptions

LP14443-3 CD4
Found on helper T-cells; weakly expressed on monocytes.
Associated with some mature T-cell neoplasms, including most cases of T-cell CLL/prolymphocytic leukemia, peripheral
T-cell lymphoma, adult T-cell leukemia/lymphoma and Sézary syndrome/mycosis fungoides Source: Regenstrief LOINC

Observation Required in Panel

Optional

Fully-Specified Name

Component: Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells^^corrected for background
Property: ACnc
Time: Pt
System: Bld
Scale: Qn
Method

Additional Names

Short Name: M TB IFN-g CD4+ bckgrnd cor Bld-aCnc
Display Name: M. tuberculosis stim IFN-g by CD4+ T-cells corrected for background Qn (Bld)
Consumer Name Alpha Get Info: Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells Corrected for Background, Blood

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.36
Last Updated: Version 2.73
Change Reason: Updated Component to include "by helper CD4 cells" to clarify that the IFN-gamma response is from CD4+ T-helper cells only in this assay. A newer assay uses this test as well as a separate assay to detect IFN-gamma response by both helper CD4 and cytotoxic CD8 cells. Changed Component from Mycobacterium tuberculosis stimulated gamma interferon release by helper CD4 cells^^corrected for background to Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells^^corrected for background to be consistant with LOINC cell marker naming conventions.
Order vs. Observation: Observation
Common Test Rank Get Info: 555

Member of these Panels

LOINC	Long Common Name
71775-1	Mycobacterium tuberculosis stimulated gamma interferon panel - Blood

Language Variants Get Info

Tag	Language	Translation
es-ES	Spanish (Spain)	IFNγ liberado por células T CD4 estimuladas por Mycobacterium tuberculosis^^Corregido por ruido de fondo:Concentración arbitraria:Punto temporal:Sangre:Qn: Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Mycobacterium tuberculosis estimuló la liberación de interferón gamma por células T CD4 +^^ corregido por antecedentes:Concentración arbitraria:Punto temporal:Sangre:Cuantitativo:
fr-FR	French (France)	Interféron gamma libéré par cellules CD4+ stimulées par mycobacterium tuberculosis corrigé par bruit de fond:Arbitraire/Volume:Ponctuel:Sang:Numérique:
it-IT	Italian (Italy)	Mycobacterium tuberculosis, gamma interferone stimolato rilascio da CD4+ cellule T^^corretto per background:ACnc:Pt:Sangue:Qn: Synonyms: Concentrazione Arbitraria Gamma interferone stimolato da Mycobacterium tuber Micobatterio della tubercolosi Microbiologia Punto nel tempo (episodio) Sangue
nl-NL	Dutch (Netherlands)	Mycobacterium tuberculosis-gestimuleerde gamma-interferon-release door CD4+-T-cellen^^gecorrigeerd voor achtergrond:eenheid/volume:moment:bloed:kwantitatief:
zh-CN	Chinese (China)	CD4+ T-细胞所释放的结核分枝杆菌刺激型 gamma 干扰素^^经过针对本底而校正的:任意型浓度:时间点:全血:定量型: Synonyms: AFB CD4+ T-细胞（CD4+ T细胞、CD4+ T淋巴细胞）所释放的结核分枝杆菌刺激型 gamma 干扰素（γ干扰素、IFN-γ） IFN L3T4 Leu3 Leu-3 T4 T-4 W3/25 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度分支杆菌分支杆菌属分枝杆菌属劳瘵发现于辅助 T-细胞；微弱表达于单核细胞。与相关。一些成熟 T-细胞肿瘤，包括大多数情况下的 T-细胞慢性淋巴细胞白血病/前淋巴细胞白血病、外周 T-细胞淋巴瘤、成人 T-细胞白血病/淋巴瘤以及 Sézary 综合征（T 细胞红皮病）/蕈样肉芽肿（mycosis fungoides）。可用数量表示的;定量性;数值型;数量型;连续数值型标尺微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）抗酸抗酸杆菌抗酸杆菌（Acid fast bacillus，AFB）抗酸菌时刻;随机;随意;瞬间痨痨病细胞含量;细胞性;细胞性质;细胞构成;细胞类经过针对背景而校正的结核结核;肺结核;痨;痨病;TB 结核分支杆菌;结核杆菌;结核菌结核分枝杆菌刺激型 gamma 干扰素（γ干扰素、IFN-γ）结核病肺结核血;血液诱导 T 细胞诱导性 T 细胞辅助 T 细胞辅助诱导 T 细胞辅助诱导物 T 细胞

Example Units

Unit	Source
[IU]/mL	Example UCUM Units

88518-6 Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood

Term Description

The quantitative levels (uncorrected for background) for an IFN-gamma response by CD4+ T-helper and CD8+ T cytotoxic lymphocytes stimulated by the presence of TB antigens, specifically ESAT-6 and CFP-10. This term was created for, but not limited in use to, the QuantiFERON-TB Gold Plus test, which includes two tubes with the Mycobacterium tuberculosis (MTB)-complex-associated antigens ESAT-6 and CFP-10 that stimulate a cell-mediated immunity (CMI) response. The first tube contains antigens that stimulate a response from CD4+ T-helper lymphocytes [LOINC: 64084-7], and the second tube (this term) contains the antigens included in tube 1 as well as an additional set of peptides targeting the CMI response from CD8+ cytotoxic T lymphocytes. In the QuantiFERON-TB Gold Plus test, the amount of IFN-gamma is measured by enzyme-linked immunosorbent assay and reported in IU/mL. Results are adjusted for background, heterophile antibody effects, or nonspecific IFN-gamma in blood samples.
Source: Regenstrief LOINC

Part Descriptions

LP14443-3 CD4
Found on helper T-cells; weakly expressed on monocytes.
Associated with some mature T-cell neoplasms, including most cases of T-cell CLL/prolymphocytic leukemia, peripheral
T-cell lymphoma, adult T-cell leukemia/lymphoma and Sézary syndrome/mycosis fungoides Source: Regenstrief LOINC

LP17729-2 CD8
Found on T-suppressor/cytotoxic cells and some Natural Killer cells; Associated with some mature T-cell neoplasms; Large granular lymphocytosis Source: Regenstrief LOINC

Observation Required in Panel

Optional

Fully-Specified Name

Component: Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells
Property: ACnc
Time: Pt
System: Bld
Scale: Qn
Method

Additional Names

Short Name: M TBIFN-g CD4+ CD8+T-cells Bld-aCnc
Display Name: M. tuberculosis stim IFN-g by CD4+ CD8+ T-cells Qn (Bld)
Consumer Name Alpha Get Info: Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells, Blood

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.64
Last Updated: Version 2.64
Change Reason: Changed Component from Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells to Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells to be consistant with LOINC cell marker naming conventions.
Order vs. Observation: Both

Member of these Panels

LOINC	Long Common Name
71775-1	Mycobacterium tuberculosis stimulated gamma interferon panel - Blood

Language Variants Get Info

Tag	Language	Translation
es-ES	Spanish (Spain)	IFNγ liberado por células T CD4 y T CD8 estimuladas por Mycobacterium tuberculosis:Concentración arbitraria:Punto temporal:Sangre:Qn: Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Mycobacterium tuberculosis estimuló la liberación de interferón gamma por células T CD4 + y CD8 +:Concentración arbitraria:Punto temporal:Sangre:Cuantitativo:
fr-FR	French (France)	Interféron gamma libéré par cellules T CD4+ et CD8+ stimulées par mycobacterium tuberculosis:Arbitraire/Volume:Ponctuel:Sang:Numérique:
it-IT	Italian (Italy)	Mycobacterium tuberculosis, gamma interferone stimolato rilascio da CD4+ e CD8+ e cellule T:ACnc:Pt:Sangue:Qn: Synonyms: Concentrazione Arbitraria Gamma interferone stimolato da Mycobacterium tuber Micobatterio della tubercolosi Microbiologia Punto nel tempo (episodio) Sangue
nl-NL	Dutch (Netherlands)	Mycobacterium tuberculosis-gestimuleerde gamma-interferon-release door CD4+ en CD8+T-cellen:eenheid/volume:moment:bloed:kwantitatief:
zh-CN	Chinese (China)	CD4+ 和 CD8+ T-细胞所释放的结核分枝杆菌刺激型 gamma 干扰素:任意型浓度:时间点:全血:定量型: Synonyms: AFB CD4+ 和 CD8+ T-细胞（CD4+ 和 CD8+ T细胞、CD4+ 和 CD8+ T淋巴细胞）所释放的结核分枝杆菌刺激型 gamma 干扰素（γ干扰素、IFN-γ） IFN L3T4 Leu2 Leu-2 Leu3 Leu-3 T4 T-4 T8 T-8 Tsuppressor W3/25 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度分支杆菌分支杆菌属分枝杆菌属劳瘵发现于抑制性 T-细胞/细胞毒性 T-细胞、一些 NK 细胞之上。与一些成熟 T-细胞肿瘤和大颗粒淋巴细胞增多症相关发现于辅助 T-细胞；微弱表达于单核细胞。与相关。一些成熟 T-细胞肿瘤，包括大多数情况下的 T-细胞慢性淋巴细胞白血病/前淋巴细胞白血病、外周 T-细胞淋巴瘤、成人 T-细胞白血病/淋巴瘤以及 Sézary 综合征（T 细胞红皮病）/蕈样肉芽肿（mycosis fungoides）。可用数量表示的;定量性;数值型;数量型;连续数值型标尺微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）抑制性 T 细胞抑制性 T-细胞抗酸抗酸杆菌抗酸杆菌（Acid fast bacillus，AFB）抗酸菌时刻;随机;随意;瞬间痨痨病细胞含量;细胞性;细胞性质;细胞构成;细胞类结核结核;肺结核;痨;痨病;TB 结核分支杆菌;结核杆菌;结核菌结核分枝杆菌刺激型 gamma 干扰素（γ干扰素、IFN-γ）结核病肺结核血;血液诱导 T 细胞诱导性 T 细胞辅助 T 细胞辅助诱导 T 细胞辅助诱导物 T 细胞

Example Units

Unit	Source
[IU]/mL	Example UCUM Units

88517-8 Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] corrected for background in Blood

Term Description

The quantitative levels (corrected for background) for an IFN-gamma response by CD4+ T-helper and CD8+ T cytotoxic lymphocytes stimulated by the presence of TB antigens, specifically ESAT-6 and CFP-10. This term was created for, but not limited in use to, the QuantiFERON-TB Gold Plus test, which includes two tubes with the Mycobacterium tuberculosis (MTB)-complex-associated antigens ESAT-6 and CFP-10 that stimulate a cell-mediated immunity (CMI) response. The first tube contains antigens that stimulate a response from CD4+ T-helper lymphocytes [LOINC: 64084-7], and the second tube (this term) contains the antigens included in tube 1 as well as an additional set of peptides targeting the CMI response from CD8+ cytotoxic T lymphocytes. In the QuantiFERON-TB Gold Plus test, the amount of IFN-gamma is measured by enzyme-linked immunosorbent assay and reported in IU/mL. Results are adjusted for background, heterophile antibody effects, or nonspecific IFN-gamma in blood samples.
Source: Regenstrief LOINC

Part Descriptions

LP14443-3 CD4
Found on helper T-cells; weakly expressed on monocytes.
Associated with some mature T-cell neoplasms, including most cases of T-cell CLL/prolymphocytic leukemia, peripheral
T-cell lymphoma, adult T-cell leukemia/lymphoma and Sézary syndrome/mycosis fungoides Source: Regenstrief LOINC

LP17729-2 CD8
Found on T-suppressor/cytotoxic cells and some Natural Killer cells; Associated with some mature T-cell neoplasms; Large granular lymphocytosis Source: Regenstrief LOINC

Observation Required in Panel

Optional

Fully-Specified Name

Component: Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells^^corrected for background
Property: ACnc
Time: Pt
System: Bld
Scale: Qn
Method

Additional Names

Short Name: M TB IFN-g CD4+CD8+ bckgrnd cor Bld-aCnc
Display Name: M. tuberculosis stim IFN-g by CD4+ CD8+ T-cells corrected for background Qn (Bld)
Consumer Name Alpha Get Info: Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells Corrected for Background, Blood

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.64
Last Updated: Version 2.73
Change Reason: Changed Component from Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells^^corrected for background to Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells^^corrected for background to be consistant with LOINC cell marker naming conventions.
Order vs. Observation: Both
Common Test Rank Get Info: 620

Member of these Panels

LOINC	Long Common Name
71775-1	Mycobacterium tuberculosis stimulated gamma interferon panel - Blood

Language Variants Get Info

Tag	Language	Translation
es-ES	Spanish (Spain)	IFNγ liberado por células T CD4 y T CD8 estimuladas por Mycobacterium tuberculosis^^Corregido por ruido de fondo:Concentración arbitraria:Punto temporal:Sangre:Qn: Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Mycobacterium tuberculosis estimuló la liberación de interferón gamma por células T CD4 + y CD8 +^^ corregido para antecedentes:Concentración arbitraria:Punto temporal:Sangre:Cuantitativo:
fr-FR	French (France)	Interféron gamma libéré par cellules T CD4+ et CD8+ stimulées par mycobacterium tuberculosis corrigé par bruit de fond:Arbitraire/Volume:Ponctuel:Sang:Numérique:
it-IT	Italian (Italy)	Mycobacterium tuberculosis, gamma interferone stimolato rilascio da CD4+ e CD8+ e cellule T^^corretto per background:ACnc:Pt:Sangue:Qn: Synonyms: Concentrazione Arbitraria Gamma interferone stimolato da Mycobacterium tuber Micobatterio della tubercolosi Microbiologia Punto nel tempo (episodio) Sangue
nl-NL	Dutch (Netherlands)	Mycobacterium tuberculosis-gestimuleerde gamma-interferon-release door CD4+ en CD8+T-cellen^^gecorrigeerd voor achtergrond:eenheid/volume:moment:bloed:kwantitatief:
zh-CN	Chinese (China)	CD4+ 和 CD8+ T-细胞所释放的结核分枝杆菌刺激型 gamma 干扰素^^经过针对本底而校正的:任意型浓度:时间点:全血:定量型: Synonyms: AFB CD4+ 和 CD8+ T-细胞（CD4+ 和 CD8+ T细胞、CD4+ 和 CD8+ T淋巴细胞）所释放的结核分枝杆菌刺激型 gamma 干扰素（γ干扰素、IFN-γ） IFN L3T4 Leu2 Leu-2 Leu3 Leu-3 T4 T-4 T8 T-8 Tsuppressor W3/25 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度分支杆菌分支杆菌属分枝杆菌属劳瘵发现于抑制性 T-细胞/细胞毒性 T-细胞、一些 NK 细胞之上。与一些成熟 T-细胞肿瘤和大颗粒淋巴细胞增多症相关发现于辅助 T-细胞；微弱表达于单核细胞。与相关。一些成熟 T-细胞肿瘤，包括大多数情况下的 T-细胞慢性淋巴细胞白血病/前淋巴细胞白血病、外周 T-细胞淋巴瘤、成人 T-细胞白血病/淋巴瘤以及 Sézary 综合征（T 细胞红皮病）/蕈样肉芽肿（mycosis fungoides）。可用数量表示的;定量性;数值型;数量型;连续数值型标尺微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）抑制性 T 细胞抑制性 T-细胞抗酸抗酸杆菌抗酸杆菌（Acid fast bacillus，AFB）抗酸菌时刻;随机;随意;瞬间痨痨病细胞含量;细胞性;细胞性质;细胞构成;细胞类经过针对背景而校正的结核结核;肺结核;痨;痨病;TB 结核分支杆菌;结核杆菌;结核菌结核分枝杆菌刺激型 gamma 干扰素（γ干扰素、IFN-γ）结核病肺结核血;血液诱导 T 细胞诱导性 T 细胞辅助 T 细胞辅助诱导 T 细胞辅助诱导物 T 细胞

Example Units

Unit	Source
[IU]/mL	Example UCUM Units

96754-7 Mycobacterium tuberculosis stimulated gamma interferon release by T-cells [Units/volume] corrected for background in Blood

Observation Required in Panel

Optional

Fully-Specified Name

Component: Mycobacterium tuberculosis stimulated gamma interferon release by T-cells^^corrected for background
Property: ACnc
Time: Pt
System: Bld
Scale: Qn
Method

Additional Names

Short Name: M TB IFN-g T-cells bckgrd cor Bld-aCnc
Display Name: M. tuberculosis stim IFN-g by T-cells corrected for background Qn (Bld)
Consumer Name Alpha Get Info: Mycobacterium tuberculosis stimulated gamma interferon release by T-cells Corrected for Background, Blood

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.70
Last Updated: Version 2.70
Order vs. Observation: Observation

Member of these Panels

LOINC	Long Common Name
71775-1	Mycobacterium tuberculosis stimulated gamma interferon panel - Blood

Language Variants Get Info

Tag	Language	Translation
es-ES	Spanish (Spain)	Liberación de interferón gamma por células T estimuladas por Mycobacterium tuberculosis^^Corregido por ruido de fondo:Concentración arbitraria:Punto temporal:Sangre:Qn: Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Mycobacterium tuberculosis estimuló la liberación de interferón gamma por células T^^corregido por antecedentes:ACnc:Punto temporal:Edificio:Cuantitativo:
fr-FR	French (France)	Interféron gamma libéré par cellules T stimulées par mycobacterium tuberculosis corrigé par bruit de fond:Arbitraire/Volume:Ponctuel:Sang:Numérique:
it-IT	Italian (Italy)	Mycobacterium tuberculosis, gamma interferone stimolato rilascio da cellule T^^corretto per background:ACnc:Pt:Sangue:Qn: Synonyms: Concentrazione Arbitraria Gamma interferone stimolato da Mycobacterium tuber Micobatterio della tubercolosi Microbiologia Punto nel tempo (episodio) Sangue
zh-CN	Chinese (China)	T-细胞所释放的结核分枝杆菌刺激型 gamma 干扰素^^经过针对本底而校正的:任意型浓度:时间点:全血:定量型: Synonyms: AFB IFN T-细胞（T细胞、T淋巴细胞）所释放的结核分枝杆菌刺激型 gamma 干扰素（γ干扰素、IFN-γ）任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度分支杆菌分支杆菌属分枝杆菌属劳瘵可用数量表示的;定量性;数值型;数量型;连续数值型标尺微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）抗酸抗酸杆菌抗酸杆菌（Acid fast bacillus，AFB）抗酸菌时刻;随机;随意;瞬间痨痨病细胞含量;细胞性;细胞性质;细胞构成;细胞类经过针对背景而校正的结核结核;肺结核;痨;痨病;TB 结核分支杆菌;结核杆菌;结核菌结核分枝杆菌刺激型 gamma 干扰素（γ干扰素、IFN-γ）结核病肺结核血;血液

Example Units

Unit	Source
[IU]/mL	Example UCUM Units

71773-6 Mycobacterium tuberculosis stimulated gamma interferon [Interpretation] in Blood Qualitative

Part Descriptions

LP149676-1 Mycobacterium tuberculosis stimulated gamma interferon
Interferon-γ (interferon-gamma) release assays (IGRAs) are based on the ability of the Mycobacterium tuberculosis antigens for early secretory antigen target 6 (ESAT-6) and culture filtrate protein 10 (CFP-10) to stimulate host production of interferon-gamma. Because these antigens are not present in non-tuberculous mycobacteria or in any BCG vaccine variant, these tests can distinguish latent tuberculosis infection (LTBI). The blood tests QuantiFERON-TB Gold In-Tube and T-SPOT.TB use these antigens to detect people with tuberculosis. Lymphocytes from the patient's blood are incubated with the antigens. If the patient has been exposed to tuberculosis before, T lymphocytes produce interferon γ in response. These tests are both interferon γ tests but they are not equivalent. The QuantiFERON-TB Gold In-Tube uses an ELISA format to quantify the total amount of interferon γ when whole blood is exposed to the antigens (ESAT-6,CFP-10 and TB 7.7). T-SPOT.TB is a type of enzyme-linked immunospot assay (ELISPOT) assay, which counts the number of activated T lymphocytes that secrete interferon γ. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

Observation Required in Panel

Required

Fully-Specified Name

Component: Mycobacterium tuberculosis stimulated gamma interferon
Property: Imp
Time: Pt
System: Bld
Scale: Ord
Method

Additional Names

Short Name: M TB IFN-g Bld-Imp
Display Name: M. tuberculosis stim IFN-g Ql (Bld) [Interp]
Consumer Name Alpha Get Info: Mycobacterium tuberculosis stimulated gamma interferon, Blood

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.40
Last Updated: Version 2.73
Change Reason: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; Updated Property from 'PrThr' to 'Imp' since the result for this observation is the overall interpretation of the assay.
Order vs. Observation: Both
Common Test Rank Get Info: 451

Example Answer List LL759-2

Answer	Code	Score	Answer ID
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value)			LA6577-6
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value)			LA6576-8
Indeterminate Copyright http://snomed.info/sct ID:82334004 Indeterminate (qualifier value)			LA11884-6

Member of these Panels

LOINC	Long Common Name
74281-7	Mycobacterium tuberculosis stimulated gamma interferon and spot count panel - Blood
71775-1	Mycobacterium tuberculosis stimulated gamma interferon panel - Blood

Language Variants Get Info

Tag	Language	Translation
es-ES	Spanish (Spain)	Mycobacterium tuberculosis estimulado con interferón gamma:Impresión/interpretación del estudio:Punto temporal:Sangre:Ord:
es-MX	Spanish (Mexico)	Interferón gamma estimulado por Mycobacterium tuberculosis:Impresión / interpretación del estudio:Punto temporal:Sangre:Ordinal:
fr-FR	French (France)	Interféron gamma stimulé par mycobacterium tuberculosis:Interprétation:Ponctuel:Sang:Qualitatif:
fr-BE	French (Belgium)	Mycobacterium tuberculosis, stimulation par gamma Interféron:Impression/interprétation d'étude:Temps ponctuel:Sang:Ordinal: Synonyms: IF
fr-CA	French (Canada)	Mycobacterium tuberculosis, stimulation par le gamma Interféron:Impression/interprétation d'étude:Temps ponctuel:Sang:Ordinal:
it-IT	Italian (Italy)	Mycobacterium tuberculosis, gamma interferone stimolato:Imp:Pt:Sangue:Ord: Synonyms: Gamma interferone stimolato da Mycobacterium tuber Impressione/interpretazione di studio Micobatterio della tubercolosi Microbiologia Punto nel tempo (episodio) Sangue
nl-NL	Dutch (Netherlands)	Mycobacterium tuberculosis gestimuleerd gamma-interferon:interpretatie:moment:bloed:ordinaal:
pt-BR	Portuguese (Brazil)	Mycobacterium tuberculosis gama interferon estimulada:Limiar:Pt:SgTotal:Ord:
ru-RU	Russian (Russian Federation)	Mycobacterium tuberculosis стимулированный гамма интерферон:Впчт:ТчкВрм:Кр:Пор: Synonyms: Впечатление/интерпретация исследования Кровь Порядковый Точка во времени;Момент
tr-TR	Turkish (Turkey)	Mycobacterium tuberculosis indüklenmiş gamma interferon:İzlnm:Zmlı:Kan:Srl:
zh-CN	Chinese (China)	结核分枝杆菌刺激型 gamma 干扰素:印象:时间点:全血:序数型: Synonyms: AFB IFN 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型分支杆菌分支杆菌属分枝杆菌属劳瘵印象是一种诊断陈述，始终是对其他某种观察指标的解释或抽象（一系列检验项目结果、一幅图像或者整个某位病人），而且几乎总是由某位专业人员产生。;检查印象;检查印象/解释;检查的印象/解释;检查解释;解释;阐释微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）抗酸抗酸杆菌抗酸杆菌（Acid fast bacillus，AFB）抗酸菌时刻;随机;随意;瞬间痨痨病结核结核;肺结核;痨;痨病;TB 结核分支杆菌;结核杆菌;结核菌结核分枝杆菌刺激型 gamma 干扰素（γ干扰素、IFN-γ）结核病肺结核血;血液

Third Party Copyright

This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.

This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.

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71775-1

Mycobacterium tuberculosis stimulated gamma interferon panel - Blood

Active

71776-9 Gamma interferon background [Units/volume] in Blood by Immunoassay

Term Description

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Example Units

71772-8 Mitogen stimulated gamma interferon [Units/volume] in Blood

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71774-4 Mitogen stimulated gamma interferon [Units/volume] corrected for background in Blood

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46217-6 Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] in Blood

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64084-7 Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

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88518-6 Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood

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88517-8 Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] corrected for background in Blood

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Example Units

96754-7 Mycobacterium tuberculosis stimulated gamma interferon release by T-cells [Units/volume] corrected for background in Blood

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Fully-Specified Name