Version 2.77

Term Description

Detection of variants in the 23S rRNA gene of H. pylori responsible for Clarithromycin resistance. Two or more mutations (e.g. A2143G and T2182C) may be detected. Testing may be performed on a variety of specimens, including gastric tissue and stool, to assist in treatment planning for H. pylori infections. This term was created for, but not limited in use to, a PCR-based Caliper LabChip with sequencing technology.
Source: Regenstrief LOINC

Part Description

LP265289-1   Helicobacter pylori 23S rRNA clarithromycin resistance mutation
Helicobacter pylori (H.pylori) are gram-negative bacterium usually found in the stomach. To treat for H.pylori infections, antibiotics such as clarithromycin/metronidazole or clarithromycin/amoxicillin are given. H.pylori is known to be resistant to clarithromycin due to decreased binding of the antibiotic to the bacterial ribosome. The insufficient binding is caused by point mutations within the 23S rRNA peptidyl transferase -encoding region. Three major variants (A2143G, A2142G and A2142C) in two adjacent position on the 23S rRNA gene are most commonly associated with clarithromycin resistance. The A2143G variant is most frequently reported, whereas variants A2142G and A2142C are less common. Various molecular assays have been developed to detect CLR resistance in H. pylori isolates in both gastric biopsy and stool specimens. PMID: 27436390 Source: Regenstrief LOINC

Fully-Specified Name

Component
Helicobacter pylori 23S rRNA clarithromycin resistance mutation
Property
Prid
Time
Pt
System
Isolate/Specimen
Scale
Nom
Method
Molgen

Additional Names

Short Name
H pylori 23S clarithro res mut Islt/Spm
Display Name
H. pylori 23S rRNA clarithromycin resistance mutation Molgen Nom (Islt/Spec)
Consumer Name Alpha Get Info
Helicobacter pylori 23S rRNA clarithromycin resistance mutation

Example Answer List: LL4769-7

Source: BioReference Laboratories
Answer Code Score Answer ID
A2142G LA28472-1
A2142C LA28471-3
A2143G LA28470-5
G2142A LA28473-9
T2182C LA28575-1
Not detected LA11883-8

Basic Attributes

Class
ABXBACT
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.65
Change Reason
Updated System from "Isolate" and Method from "Probe.amp.tar" according to the new, more sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Mutación 23S RNA de resistencia a claritromicina en Helicobacter pylori:Presencia o identidad:Punto temporal:Muestra aislada:Nom:Genética molecular
es-MX Spanish (Mexico) Mutación de resistencia a claritromicina de ARNr 23S de Helicobacter pylori:Presencia o identidad:Punto temporal:Aislado o espécimen:Nominal:Genética molecular
fr-FR French (France) Helicobacter pylori ARNr 23S mutation de résistance à la clarithromycine:Identification:Ponctuel:Isolat/échantillon:Résultat nominal:Biologie moléculaire
it-IT Italian (Italy) Helicobacter pylori, mutazione 23S rRNA resistenza alla claritromicina:Prid:Pt:Isolato/Campione:Nom:Molgen
Synonyms: Genetica molecolare Isolato o Campione Presenza o Identità Punto nel tempo (episodio) Suscettibilità agli antibiotici
zh-CN Chinese (China) 幽门螺杆菌 23S rRNA 克拉霉素耐药性突变:存在与否或特征标识:时间点:分离株/标本:名义型:分子遗传学类实验室方法
Synonyms: 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 分离株/标本（样本、样品、试样） 分离物;分离菌;分离菌株;隔离种群 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 受检物 大环内酯类抗生素;第二代红霉素 存在;存在与否;特征标识;身份;身份标识 幽门弯曲菌;Hp 幽门螺杆菌（幽门弯曲菌、Hp） 23S rRNA 克拉霉素耐药性（抗性、耐性、耐药、抗药、抗药性、耐受、耐药型）突变 抗力 抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类 抗耐性 抵抗力 抵抗性 时刻;随机;随意;瞬间 样品 样本 核蛋白体 RNA 核蛋白体 RNA（Ribosomal RNA，RRNA） 核蛋白体核糖核酸 核醣体 RNA 电阻 耐性 试样 阻力

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